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Study Information
Study Attribute Value
CEBS Accession Number: 002-02837-0002-0000-4
Chemical Name: Stannous chloride
CASRN: 7772-99-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 421347_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 05/01/1985    Harvest Time: 18 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Stannous chloride 
100         
 200 8 0.040 3.0 1 0.005 1.0 7 0.035 3.0 0 0.000 0.0 
500         
 200 20 0.100 9.0 3 0.015 2.0 17 0.085 7.0 0 0.000 0.0 
750         
 200 32 0.160 13.0 11 0.055 6.0 21 0.105 9.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 200 72 0.360 26.0 44 0.220 18.0 28 0.140 13.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 39 0.780 50.0 28 0.560 40.0 11 0.220 18.0 0 0.000 0.0
Trend: 5.328 3.682 4.071  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/01/1985    Harvest Time: 19 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 1.0 0 0.000 0.0 1 0.005 1.0 0 0.000 0.0
Test Chemical: Stannous chloride 
750         
 200 38 0.190 12.0 16 0.080 7.0 12 0.060 5.0 10 0.050 1.0 
1000         
 200 56 0.280 19.0 15 0.075 8.0 31 0.155 12.0 10 0.050 1.0 
1500         
 200 68 0.340 22.0 43 0.215 19.0 24 0.120 8.0 1 0.005 1.0
Positive Control: Cyclophosphamide 
7.5       
 200 205 1.025 60.0 94 0.470 34.0 111 0.555 41.0 0 0.000 0.0
Trend: 6.400 6.696 3.403  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 08/07/1985    Harvest Time: 17.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Stannous chloride 
25         
 200 16 0.080 6.0 3 0.015 1.0 13 0.065 5.0 0 0.000 0.0 
50         
 200 23 0.115 10.0 7 0.035 3.0 16 0.080 7.0 0 0.000 0.0 
100         
 200 19 0.095 9.0 3 0.015 2.0 15 0.075 7.0 1 0.005 1.0
Positive Control: Mitomycin-C 
 0.063     
 200 94 0.470 32.0 47 0.235 20.0 37 0.185 16.0 10 0.050 1.0
Mitomycin-C 
 0.125     
 50 47 0.940 62.0 28 0.560 42.0 19 0.380 34.0 0 0.000 0.0
Trend: 4.050 2.081 3.419  
Probability: 0.000 0.019 0.000