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Study Information
Study Attribute Value
CEBS Accession Number: 002-02837-0011-0000-4
Chemical Name: Stannous chloride
CASRN: 7772-99-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 685652_SCE
Study Result: Positive


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 12/09/87 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 7.14 ± 0.138
Test Chemical Stannous chloride 
37.5       
 4 7.06 ± 0.403
  
75         
 4 7.33 ± 0.261
  
150         
 4 8.92 ± 1.072
Positive Control Dimethylbenzanthracene 
2.5       
 4 13.97 ± 0.535


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 01/27/88 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.87 ± 0.160
Test Chemical Stannous chloride 
37.5       
 4 5.88 ± 0.436
  
75         
 3 5.25 ± 0.356
  
150         
 4 4.89 ± 0.415
Positive Control Dimethylbenzanthracene 
2.5       
 4 9.03 ± 0.784


Summary of Sister Chromatid Exchange Data (Trial 3)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 04/26/88 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.52 ± 0.236
Test Chemical Stannous chloride 
112.5       
 4 5.90 ± 0.042
  
150         
 4 5.72 ± 0.700
  
187.5       
 4 7.61 ± 0.820
Positive Control Dimethylbenzanthracene 
2.5       
 4 12.71 ± 1.189


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed