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Study Information
Study Attribute Value
CEBS Accession Number: 002-02837-0012-0000-5
Chemical Name: Stannous chloride
CASRN: 7772-99-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 685652_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 04/13/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.6617
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 11.25 ± 1.85 0.0000
Test Chemical Stannous chloride 
37.5       
 8 1.25 ± 0.53 0.9038
  
75         
 8 0.25 ± 0.25 0.9969
  
150         
 8 2.00 ± 0.85 0.6832
Vehicle Control No Stressor 
 0         
 8 2.50 ± 0.82 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 10/26/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0207
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
25         
 7 17.14 ± 2.79 0.0000
Test Chemical Stannous chloride 
37.5       
 7 4.00 ± 1.51 0.0170
  
75         
 7 1.71 ± 0.52 0.4078
  
150         
 8 4.50 ± 0.73 0.0064
Vehicle Control No Stressor 
 0         
 8 1.50 ± 0.82 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 04/11/89 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.3982
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
25         
 7 15.43 ± 2.38 0.0000
Test Chemical Stannous chloride 
112.5       
 8 3.50 ± 1.18 0.0973
  
150         
 8 1.75 ± 0.59 0.6028
Vehicle Control No Stressor 
 0         
 8 2.00 ± 0.53 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/22/89 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0049
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
25         
 8 12.00 ± 2.10 0.0000
Test Chemical Stannous chloride 
112.5       
 8 2.50 ± 0.98 0.2310
  
150         
 8 5.50 ± 0.98 0.0023
Vehicle Control No Stressor 
 0         
 8 1.75 ± 0.45 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed