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Study Information
Study Attribute Value
CEBS Accession Number: 002-02844-0002-0000-2
Chemical Name: Styrene
CASRN: 100-42-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 987609_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Test Failure 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Negative 

Trial #:1   Activation: No Activation    Date: 08/14/1986    Harvest Time: 10 hour(s)   Trial Call: Test Failure   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 5 0.025 2.0 3 0.015 1.5 2 0.010 1.0 0 0.000 0.0
Test Chemical: Styrene 
151         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.75      
 25 13 0.520 36.0 5 0.200 20.0 8 0.320 24.0 0 0.000 0.0
Trend: 0.000 0.000 0.000  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/14/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 4 0.020 1.5 0 0.000 0.0 4 0.020 1.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 5 0.025 1.5 1 0.005 0.5 4 0.020 1.5 0 0.000 0.0
Test Chemical: Styrene 
37.4       
 200 7 0.035 3.5 5 0.025 2.5 2 0.010 1.0 0 0.000 0.0 
74.8       
 200 4 0.020 1.5 2 0.010 1.0 2 0.010 0.5 0 0.000 0.0 
113.3       
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
151         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 37 0.185 11.5 5 0.025 2.5 22 0.110 9.0 10 0.050 0.5
Cyclophosphamide 
37.5       
 25 14 0.560 40.0 5 0.200 16.0 9 0.360 28.0 0 0.000 0.0
Trend: -0.905 -0.539 -1.207  
Probability: 0.817 0.705 0.886  


Trial #:2   Activation: No Activation    Date: 08/26/1986    Harvest Time: 10 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Test Chemical: Styrene 
22.4       
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
29.9       
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
74.8       
 200 5 0.025 2.5 1 0.005 0.5 4 0.020 2.0 0 0.000 0.0 
149.5       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 200 37 0.185 13.5 17 0.085 8.0 20 0.100 8.0 0 0.000 0.0
Mitomycin-C 
 0.75      
 25 11 0.440 24.0 6 0.240 12.0 5 0.200 16.0 0 0.000 0.0
Trend: 0.933 -0.064 1.112  
Probability: 0.175 0.526 0.133