Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02845-0006-0000-7
Chemical Name:	Styrene oxide
CASRN:	96-09-3
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	692229
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Ethanol	0	92	95	68	25	19
			90	116	55	20
			95	94	35	12
			99	95	55	19
Test Chemical	Styrene oxide	10	109	50	174	53	68*
			85	49	224	88
			108	51	206	64
		20	89	43	377	141	172*
			63	34	319	170
			66	35	407	205
		30	54	22	504	310	357*
			44	18	483	366
			62#	27	727	394
		40	78#	25	719	309	461*
			26	2	487	637
			51	10	668	438
		50	51#	7	665	433	532*
			20	1	424	707
			36	4	494	455
		60	15#	1	270	600	594*
			16r	1	327	703
			42	3	747	588
Positive Control	Methyl Methane Sulfonate	5	92	51	568	205	235*
			94	41	561	200
			63	32	568	300

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Ethanol	0	69	82	59	29	28
			94	97	81	29
			89	111	93	35
			87	109	54	21
Test Chemical	Styrene oxide	10	54	62	147	92	91*
			75	85	215	95
			72	55	187	87
		20	44	34	418	314	334*
			54	29	541	335
			38	29	399	352
		30	26	11	591	748	611*
			37	14	577	525
			38	12	639	561
		40	36	10	617	574	758*
			26	6	712	913
			29	6	680	786
		50					681*
			26	3	604	765
			29	4	528	597
		60


Positive Control	Methyl Methane Sulfonate	5	63	40	568	299	332*
			41	34	437	360
			40	19	403	337

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination