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Study Information
Study Attribute Value
CEBS Accession Number: 002-02847-0001-0000-4
Chemical Name: Succinic anhydride
CASRN: 108-30-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 690556_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 02/12/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1033 411 0.398 8.22 25.5 0.000
Test Chemical Succinic anhydride 
50         
 50 1033 362 0.350 7.24 25.5 -11.922 
166.5       
 50 1039 392 0.377 7.84 25.5 -5.174 
500         
 50 1040 369 0.355 7.38 25.5 -10.823 
1665         
 0 0 0 0.000 0.00 25.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1017 509 0.500 10.18 25.5 25.793
Mitomycin-C 
 0.01      
 5 105 200 1.905 40.00 25.5 378.739
Trend: -1.201        
Probability: 0.885        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/12/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 384 0.367 7.68 25.5 0.000
Test Chemical Succinic anhydride 
50         
 50 1041 424 0.407 8.48 25.5 10.841 
166.5       
 50 1040 401 0.386 8.02 25.5 4.929 
500         
 50 1039 372 0.358 7.44 25.5 -2.566 
1665         
 0 0 0 0.000 0.00 25.5 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1035 711 0.687 14.22 25.5 86.945
Cyclophosphamide 
2         
 5 104 181 1.740 36.20 25.5 373.620
Trend: -0.567        
Probability: 0.714