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Study Information
Study Attribute Value
CEBS Accession Number: 002-02847-0002-0000-5
Chemical Name: Succinic anhydride
CASRN: 108-30-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 690556_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2   
Induced Rat Liver S9  2_S9   

Trial #:1   Activation: No Activation    Date: 03/13/1985    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Succinic anhydride 
500         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
750         
 100 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 
1000         
 100 2 0.020 1.0 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 
2000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.5       
 100 6 0.060 5.0 2 0.020 2.0 4 0.040 3.0 0 0.000 0.0
Mitomycin-C 
1         
 25 8 0.320 28.0 2 0.080 8.0 6 0.240 24.0 0 0.000 0.0
Trend: 0.466 1.368 -1.272  
Probability: 0.321 0.086 0.898  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/13/1985    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 2.0 2 0.020 1.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Succinic anhydride 
500         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
750         
 100 4 0.040 3.0 2 0.020 1.0 2 0.020 2.0 0 0.000 0.0 
1000         
 100 4 0.040 3.0 3 0.030 2.0 1 0.010 1.0 0 0.000 0.0 
2000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 100 10 0.100 9.0 6 0.060 6.0 4 0.040 4.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 15 0.600 40.0 8 0.320 16.0 7 0.280 28.0 0 0.000 0.0
Trend: 0.311 -0.082 0.519  
Probability: 0.378 0.533 0.302  


Trial #:2   Activation: No Activation    Date: 02/26/1985    Harvest Time: 10.5 hour(s)   Trial Call:   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Succinic anhydride 
2000         
 100 3 0.030 2.0 0 0.000 0.0 3 0.030 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.5       
 25 7 0.280 20.0 0 0.000 0.0 7 0.280 20.0 0 0.000 0.0
Trend: 0.000 0.000 0.000  
Probability: 0.000 0.000 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 02/26/1985    Harvest Time: 12.5 hour(s)   Trial Call:   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 3.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Succinic anhydride 
2000         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
37.5       
 25 20 0.800 48.0 6 0.240 16.0 14 0.560 40.0 0 0.000 0.0
Trend: 0.000 0.000 0.000  
Probability: 0.000 0.000 0.000