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Study Information
Study Attribute Value
CEBS Accession Number: 002-02850-0001-0000-8
Chemical Name: Sulfacetamide
CASRN: 144-80-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 840461_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Negative 
No Activation  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 05/05/1981    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified)
0         
50 1020 500 0.490 10.00 26.0 -12.459
Dimethyl Sulfoxide
0         
50 1009 565 0.560 11.30 26.0 0.000
Test Chemical Sulfacetamide
30         
50 1027 553 0.538 11.06 26.0 -3.839
100         
50 1034 489 0.473 9.78 26.0 -15.544
300         
50 1038 537 0.517 10.74 30.0 -7.611
1000         
50 1024 588 0.574 11.76 30.0 2.546
3000         
0 0 0 0.000 0.00 30.0 N/A
Positive Control Triethylenemelamine
 0.015     
10 206 1512 7.340 151.20 26.0 1210.772
Trend: 0.099        
Probability: 0.461        

Trial #: 2    Activation: No Activation    Date: 06/10/1981    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1013 508 0.501 10.16 25.5 0.000
Test Chemical Sulfacetamide
2000         
50 1025 590 0.576 11.80 30.0 14.782
2250         
50 1035 642 0.620 12.84 30.0 23.692
2500         
50 1019 679 0.666 13.58 30.0 32.874
Positive Control Triethylenemelamine
 0.015     
50 1035 2074 2.004 41.48 25.5 299.590
Trend: 5.002        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/05/1981    Trial Call: Weakly Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1020 475 0.466 9.50 26.0 0.000
Negative (Not Specified)
0         
50 1041 485 0.466 9.70 26.0 0.046
Test Chemical Sulfacetamide
300         
50 1018 441 0.433 8.82 26.0 -6.975
1000         
50 1005 571 0.568 11.42 26.0 22.005
3000         
50 1012 530 0.524 10.60 26.0 12.461
Positive Control Cyclophosphamide
1.5       
50 1019 1012 0.993 20.24 26.0 113.262
Cyclophosphamide
2         
50 1024 1 0.001 0.02 26.0 -99.790
Trend: 3.168        
Probability: 0.001