Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02850-0001-0000-8 |
Chemical Name: | Sulfacetamide |
CASRN: | 144-80-9 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 840461_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
No Activation | 2 | Positive |
Induced Rat Liver S9 | 1_S9 | Weakly Positive |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Negative (Not Specified) | 0 | 50 | 1020 | 500 | 0.490 | 10.00 | 26.0 | -12.459 |
Dimethyl Sulfoxide | 0 | 50 | 1009 | 565 | 0.560 | 11.30 | 26.0 | 0.000 | |
Test Chemical | Sulfacetamide | 30 | 50 | 1027 | 553 | 0.538 | 11.06 | 26.0 | -3.839 |
100 | 50 | 1034 | 489 | 0.473 | 9.78 | 26.0 | -15.544 | ||
300 | 50 | 1038 | 537 | 0.517 | 10.74 | 30.0 | -7.611 | ||
1000 | 50 | 1024 | 588 | 0.574 | 11.76 | 30.0 | 2.546 | ||
3000 | 0 | 0 | 0 | 0.000 | 0.00 | 30.0 | N/A | ||
Positive Control | Triethylenemelamine | 0.015 | 10 | 206 | 1512 | 7.340 | 151.20 | 26.0 | 1210.772 |
Trend: | 0.099 | ||||||||
Probability: | 0.461 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1013 | 508 | 0.501 | 10.16 | 25.5 | 0.000 |
Test Chemical | Sulfacetamide | 2000 | 50 | 1025 | 590 | 0.576 | 11.80 | 30.0 | 14.782 |
2250 | 50 | 1035 | 642 | 0.620 | 12.84 | 30.0 | 23.692 | ||
2500 | 50 | 1019 | 679 | 0.666 | 13.58 | 30.0 | 32.874 | ||
Positive Control | Triethylenemelamine | 0.015 | 50 | 1035 | 2074 | 2.004 | 41.48 | 25.5 | 299.590 |
Trend: | 5.002 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1020 | 475 | 0.466 | 9.50 | 26.0 | 0.000 |
Negative (Not Specified) | 0 | 50 | 1041 | 485 | 0.466 | 9.70 | 26.0 | 0.046 | |
Test Chemical | Sulfacetamide | 300 | 50 | 1018 | 441 | 0.433 | 8.82 | 26.0 | -6.975 |
1000 | 50 | 1005 | 571 | 0.568 | 11.42 | 26.0 | 22.005 | ||
3000 | 50 | 1012 | 530 | 0.524 | 10.60 | 26.0 | 12.461 | ||
Positive Control | Cyclophosphamide | 1.5 | 50 | 1019 | 1012 | 0.993 | 20.24 | 26.0 | 113.262 |
Cyclophosphamide | 2 | 50 | 1024 | 1 | 0.001 | 0.02 | 26.0 | -99.790 | |
Trend: | 3.168 | ||||||||
Probability: | 0.001 |