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Study Information
Study Attribute Value
CEBS Accession Number: 002-02852-0001-0000-0
Chemical Name: Sulfamethazine
CASRN: 57-68-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 930871_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 06/15/1989    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 401 0.384 8.02 31.0 0.000
Dimethyl Sulfoxide 
0         
 50 1046 342 0.327 6.84 26.0 -14.795
Test Chemical Sulfamethazine 
167         
 50 1048 412 0.393 8.24 26.0 2.449 
500         
 50 1049 427 0.407 8.54 26.0 6.078 
1667         
 50 1046 489 0.467 9.78 31.0 21.829
Positive Control Mitomycin-C 
 0.001     
 50 1049 620 0.591 12.40 26.0 54.024
Mitomycin-C 
 0.005     
 10 210 278 1.324 27.80 26.0 244.983
Trend: 3.004        
Probability: 0.001        

Trial #: 2    Activation: No Activation    Date: 06/20/1989    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 399 0.380 7.98 26.0 -3.666
Dimethyl Sulfoxide 
0         
 50 1048 413 0.394 8.26 31.0 0.000
Test Chemical Sulfamethazine 
750         
 50 1048 486 0.464 9.72 26.0 17.676 
1000         
 50 1045 490 0.469 9.80 26.0 18.985 
1500         
 50 1043 555 0.532 11.10 31.0 35.027 
2000         
 47 982 488 0.497 10.38 31.0 26.101
Positive Control Mitomycin-C 
 0.001     
 50 1050 603 0.574 12.06 26.0 45.727
Mitomycin-C 
 0.005     
 10 209 253 1.211 25.30 26.0 207.175
Trend: 4.147        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/15/1989    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1048 454 0.433 9.08 26.0 6.729
Dimethyl Sulfoxide 
0         
 50 1052 427 0.406 8.54 26.0 0.000
Test Chemical Sulfamethazine 
500         
 50 1049 386 0.368 7.72 26.0 -9.343 
1667         
 50 1051 483 0.460 9.66 26.0 13.222 
5000         
 50 1048 435 0.415 8.70 26.0 2.262
Positive Control Cyclophosphamide 
 0.125     
 50 1047 591 0.564 11.82 26.0 39.068
Cyclophosphamide 
 0.5       
 10 210 196 0.933 19.60 26.0 129.945
Trend: 1.388        
Probability: 0.083