Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02856-0001-0000-4 |
Chemical Name: | Sulfanilamide |
CASRN: | 63-74-1 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 483961_SCE |
Study Result: | Equivocal |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Questionable |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1049 | 420 | 0.400 | 8.40 | 26.0 | 0.000 |
Test Chemical | Sulfanilamide | 160 | 50 | 1048 | 426 | 0.406 | 8.52 | 26.0 | 1.525 |
500 | 50 | 1053 | 450 | 0.427 | 9.00 | 26.0 | 6.736 | ||
1600 | 50 | 1047 | 477 | 0.456 | 9.54 | 26.0 | 13.788 | ||
5000 | 25 | 525 | 247 | 0.470 | 9.88 | 26.0 | 17.507 | ||
Positive Control | Mitomycin-C | 0.005 | 50 | 1049 | 836 | 0.797 | 16.72 | 26.0 | 99.048 |
Trend: | 2.604 | ||||||||
Probability: | 0.005 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1051 | 499 | 0.475 | 9.98 | 26.0 | 0.000 |
Test Chemical | Sulfanilamide | 500 | 50 | 1051 | 451 | 0.429 | 9.02 | 26.0 | -9.619 |
1600 | 50 | 1049 | 485 | 0.462 | 9.70 | 26.0 | -2.620 | ||
5000 | 50 | 1049 | 480 | 0.458 | 9.60 | 28.0 | -3.624 | ||
Positive Control | Cyclophosphamide | 1 | 25 | 523 | 458 | 0.876 | 18.32 | 26.0 | 84.445 |
Trend: | -0.196 | ||||||||
Probability: | 0.578 |