Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02856-0002-0000-5 |
Chemical Name: | Sulfanilamide |
CASRN: | 63-74-1 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 483961_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 3 | 0.030 | 3.0 | 1 | 0.010 | 1.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Sulfanilamide | 500 | 100 | 4 | 0.040 | 3.0 | 1 | 0.010 | 1.0 | 3 | 0.030 | 2.0 | 0 | 0.000 | 0.0 |
1600 | 100 | 4 | 0.040 | 4.0 | 1 | 0.010 | 1.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | ||
5000 | 100 | 4 | 0.040 | 4.0 | 1 | 0.010 | 1.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.15 | 50 | 22 | 0.440 | 24.0 | 5 | 0.100 | 10.0 | 17 | 0.340 | 20.0 | 0 | 0.000 | 0.0 |
Trend: | 0.487 | 0.000 | 0.574 | ||||||||||||
Probability: | 0.313 | 0.500 | 0.283 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 3 | 0.030 | 3.0 | 1 | 0.010 | 1.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Sulfanilamide | 500 | 100 | 8 | 0.080 | 8.0 | 3 | 0.030 | 3.0 | 5 | 0.050 | 5.0 | 0 | 0.000 | 0.0 |
1600 | 100 | 8 | 0.080 | 7.0 | 3 | 0.030 | 3.0 | 5 | 0.050 | 4.0 | 0 | 0.000 | 0.0 | ||
5000 | 100 | 8 | 0.080 | 8.0 | 3 | 0.030 | 3.0 | 5 | 0.050 | 5.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 15 | 50 | 11 | 0.220 | 18.0 | 6 | 0.120 | 10.0 | 5 | 0.100 | 10.0 | 0 | 0.000 | 0.0 |
Trend: | 1.269 | 0.860 | 0.912 | ||||||||||||
Probability: | 0.102 | 0.195 | 0.181 |