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Study Information
Study Attribute Value
CEBS Accession Number: 002-02857-0001-0000-5
Chemical Name: Sulfapyridine
CASRN: 144-83-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 788992_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/24/1990    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1050 371 0.353 7.42 26.0 -1.685
Dimethyl Sulfoxide 
0         
 50 1049 377 0.359 7.54 26.0 0.000
Test Chemical Sulfapyridine 
500         
 50 1047 440 0.420 8.80 26.0 16.934 
1667         
 50 1046 468 0.447 9.36 26.0 24.494 
5000         
 50 1051 476 0.453 9.52 26.0 26.020
Positive Control Mitomycin-C 
 0.001     
 50 1051 515 0.490 10.30 26.0 36.345
Mitomycin-C 
 0.004     
 10 211 254 1.204 25.40 26.0 234.954
Trend: 3.451        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 11/08/1990    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 425 0.405 8.50 26.0 0.000
Dimethyl Sulfoxide 
0         
 50 1049 420 0.400 8.40 31.0 -1.176
Test Chemical Sulfapyridine 
500         
 50 1049 496 0.473 9.92 26.0 16.706 
1667         
 50 1047 524 0.500 10.48 26.0 23.530 
5000         
 50 1047 510 0.487 10.20 31.0 20.229
Positive Control Mitomycin-C 
 0.001     
 50 1051 526 0.500 10.52 26.0 23.529
Mitomycin-C 
 0.004     
 10 210 223 1.062 22.30 26.0 162.103
Trend: 2.919        
Probability: 0.002        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/24/1990    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 416 0.397 8.32 26.0 0.000
Negative (Not Specified) 
0         
 50 1050 401 0.382 8.02 26.0 -3.698
Test Chemical Sulfapyridine 
500         
 50 1045 389 0.372 7.78 26.0 -6.132 
1667         
 50 1056 416 0.394 8.32 26.0 -0.663 
5000         
 50 1050 483 0.460 9.66 26.0 15.995
Positive Control Cyclophosphamide 
 0.125     
 50 1049 566 0.540 11.32 26.0 36.058
Cyclophosphamide 
 0.5       
 10 209 224 1.072 22.40 26.0 170.261
Trend: 2.385        
Probability: 0.009