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Study Information
Study Attribute Value
CEBS Accession Number: 002-02859-0001-0000-7
Chemical Name: Sulfisoxazole
CASRN: 127-69-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 214852_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Weakly Positive 
No Activation  3  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 04/16/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1028 524 0.510 10.48 26.0 0.000
Test Chemical Sulfisoxazole 
50         
 50 1017 598 0.588 11.96 33.5 15.356 
167         
 50 1022 651 0.637 13.02 33.5 24.966 
500         
 50 1009 686 0.680 13.72 33.5 33.381 
1670         
 0 0 0 0.000 0.00 33.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1031 782 0.758 15.64 26.0 48.802
Mitomycin-C 
 0.01      
 5 104 190 1.827 38.00 26.0 258.412
Trend: 5.152        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 05/14/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1012 441 0.436 8.82 26.0 0.000
Test Chemical Sulfisoxazole 
75         
 50 998 520 0.521 10.40 26.0 19.568 
100         
 50 1020 555 0.544 11.10 26.0 24.863 
251         
 50 1006 518 0.515 10.36 34.0 18.161 
503         
 0 0 0 0.000 0.00 34.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1023 513 0.501 10.26 26.0 15.076
Mitomycin-C 
 0.01      
 5 104 169 1.625 33.80 26.0 272.902
Trend: 2.303        
Probability: 0.011        

Trial #: 3    Activation: No Activation    Date: 10/15/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1027 461 0.449 9.22 26.0 0.000
Test Chemical Sulfisoxazole 
398         
 50 1033 646 0.625 12.92 35.0 39.316 
498         
 50 1025 610 0.595 12.20 35.0 32.579 
600         
 50 1016 713 0.702 14.26 35.0 56.338
Positive Control Mitomycin-C 
 0.001     
 50 1028 561 0.546 11.22 26.0 21.574
Mitomycin-C 
 0.01      
 5 105 159 1.514 31.80 26.0 237.347
Trend: 6.700        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/16/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1009 514 0.509 10.28 26.0 0.000
Test Chemical Sulfisoxazole 
500         
 50 1013 554 0.547 11.08 33.5 7.357 
1670         
 50 1020 609 0.597 12.18 33.5 17.205 
5000         
 50 1029 727 0.707 14.54 33.5 38.691
Positive Control Cyclophosphamide 
 0.4       
 50 1018 661 0.649 13.22 26.0 27.462
Cyclophosphamide 
2         
 5 103 219 2.126 43.80 26.0 317.383
Trend: 5.943        
Probability: 0.000