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Study Information
Study Attribute Value
CEBS Accession Number: 002-02859-0002-0000-8
Chemical Name: Sulfisoxazole
CASRN: 127-69-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 214852_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 06/04/1985    Harvest Time: 21.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 3 0.015 2.0 0 0.000 0.0 3 0.015 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 6 0.030 2.0 1 0.005 1.0 5 0.025 2.0 0 0.000 0.0
Test Chemical: Sulfisoxazole 
3000         
 200 7 0.035 3.0 1 0.005 1.0 6 0.030 3.0 0 0.000 0.0 
4000         
 200 9 0.045 4.0 2 0.010 1.0 7 0.035 3.0 0 0.000 0.0 
5000         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 84 0.420 20.0 37 0.185 14.0 47 0.235 9.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 25 1.000 44.0 11 0.440 32.0 14 0.560 40.0 0 0.000 0.0
Trend: -0.324 -1.062 -0.591  
Probability: 0.627 0.856 0.723  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/06/1985    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 7 0.035 2.0 1 0.005 1.0 6 0.030 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 9 0.045 4.0 4 0.020 2.0 5 0.025 2.0 0 0.000 0.0
Test Chemical: Sulfisoxazole 
3000         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
4000         
 200 6 0.030 3.0 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0 
5000         
 200 7 0.035 4.0 3 0.015 2.0 4 0.020 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 10 0.050 5.0 7 0.035 4.0 3 0.015 1.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 23 0.920 52.0 12 0.480 32.0 11 0.440 32.0 0 0.000 0.0
Trend: 0.584 0.263 0.546  
Probability: 0.280 0.396 0.293