Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02859-0002-0000-8 |
Chemical Name: | Sulfisoxazole |
CASRN: | 127-69-5 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 214852_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 3 | 0.015 | 2.0 | 0 | 0.000 | 0.0 | 3 | 0.015 | 2.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 6 | 0.030 | 2.0 | 1 | 0.005 | 1.0 | 5 | 0.025 | 2.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Sulfisoxazole | 3000 | 200 | 7 | 0.035 | 3.0 | 1 | 0.005 | 1.0 | 6 | 0.030 | 3.0 | 0 | 0.000 | 0.0 |
4000 | 200 | 9 | 0.045 | 4.0 | 2 | 0.010 | 1.0 | 7 | 0.035 | 3.0 | 0 | 0.000 | 0.0 | ||
5000 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.05 | 200 | 84 | 0.420 | 20.0 | 37 | 0.185 | 14.0 | 47 | 0.235 | 9.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.08 | 25 | 25 | 1.000 | 44.0 | 11 | 0.440 | 32.0 | 14 | 0.560 | 40.0 | 0 | 0.000 | 0.0 | |
Trend: | -0.324 | -1.062 | -0.591 | ||||||||||||
Probability: | 0.627 | 0.856 | 0.723 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 7 | 0.035 | 2.0 | 1 | 0.005 | 1.0 | 6 | 0.030 | 2.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 9 | 0.045 | 4.0 | 4 | 0.020 | 2.0 | 5 | 0.025 | 2.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Sulfisoxazole | 3000 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
4000 | 200 | 6 | 0.030 | 3.0 | 2 | 0.010 | 1.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
5000 | 200 | 7 | 0.035 | 4.0 | 3 | 0.015 | 2.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 7.5 | 200 | 10 | 0.050 | 5.0 | 7 | 0.035 | 4.0 | 3 | 0.015 | 1.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 37.5 | 25 | 23 | 0.920 | 52.0 | 12 | 0.480 | 32.0 | 11 | 0.440 | 32.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.584 | 0.263 | 0.546 | ||||||||||||
Probability: | 0.280 | 0.396 | 0.293 |