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Study Information
Study Attribute Value
CEBS Accession Number: 002-02859-0011-0000-8
Chemical Name: Sulfisoxazole
CASRN: 127-69-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 855795_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/13/86 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0932
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 24.25 ± 3.75 0.0000
Test Chemical Sulfisoxazole 
550         
 8 2.50 ± 0.73 0.5000
  
1100         
 8 1.50 ± 0.73 0.8438
  
2200         
 8 4.00 ± 1.00 0.1158
Vehicle Control No Stressor 
 0         
 8 2.50 ± 0.63 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 03/21/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.1130
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 28.25 ± 3.47 0.0000
Test Chemical Sulfisoxazole 
550         
 8 4.50 ± 1.12 0.4314
  
1100         
 8 8.00 ± 1.73 0.0135
  
2200         
 8 5.75 ± 0.80 0.1652
Vehicle Control No Stressor 
 0         
 8 4.25 ± 1.28 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 02/20/90 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0831
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 20.50 ± 4.00 0.0000
Test Chemical Sulfisoxazole 
550         
 8 1.00 ± 0.53 0.3521
  
1100         
 8 2.25 ± 1.44 0.0405
  
2200         
 8 1.75 ± 0.59 0.1015
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.37 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed