COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02875-0001-0000-5
Chemical Name: Tetrachlorodiphenylethane
CASRN: 72-54-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 624997_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 01/23/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1048 461 0.440 9.22 26.0 -12.854
Dimethyl Sulfoxide 
0         
 50 1048 529 0.505 10.58 26.0 0.000
Test Chemical Tetrachlorodiphenylethane 
 0.5       
 50 1042 432 0.415 8.64 26.0 -17.866 
1.6       
 50 1049 463 0.441 9.26 26.0 -12.560 
5         
 50 1048 510 0.487 10.20 26.0 -3.592 
16         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1051 674 0.641 13.48 26.0 27.047
Mitomycin-C 
 0.005     
 10 210 322 1.533 32.20 26.0 203.768
Trend: -0.304        
Probability: 0.619        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/08/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 503 0.479 10.06 26.0 0.000
Test Chemical Tetrachlorodiphenylethane 
 0.5       
 50 1044 456 0.437 9.12 26.0 -8.823 
1.6       
 50 1042 525 0.504 10.50 26.0 5.175 
5         
 50 1045 474 0.454 9.48 26.0 -5.315 
16         
 50 1045 450 0.431 9.00 26.0 -10.109 
50         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.15      
 50 1049 620 0.591 12.40 26.0 23.378
Cyclophosphamide 
 0.6       
 10 210 235 1.119 23.50 26.5 133.598
Trend: -1.203        
Probability: 0.885