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Study Information
Study Attribute Value
CEBS Accession Number: 002-02875-0001-0000-5
Chemical Name: Tetrachlorodiphenylethane
CASRN: 72-54-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 624997_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 01/23/1986    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified)
0         
50 1048 461 0.440 9.22 26.0 -12.854
Dimethyl Sulfoxide
0         
50 1048 529 0.505 10.58 26.0 0.000
Test Chemical Tetrachlorodiphenylethane
 0.5       
50 1042 432 0.415 8.64 26.0 -17.866
1.6       
50 1049 463 0.441 9.26 26.0 -12.560
5         
50 1048 510 0.487 10.20 26.0 -3.592
16         
0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C
 0.0E-4    
50 1051 674 0.641 13.48 26.0 27.047
Mitomycin-C
 0.005     
10 210 322 1.533 32.20 26.0 203.768
Trend: -0.304        
Probability: 0.619        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/08/1986    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1050 503 0.479 10.06 26.0 0.000
Test Chemical Tetrachlorodiphenylethane
 0.5       
50 1044 456 0.437 9.12 26.0 -8.823
1.6       
50 1042 525 0.504 10.50 26.0 5.175
5         
50 1045 474 0.454 9.48 26.0 -5.315
16         
50 1045 450 0.431 9.00 26.0 -10.109
50         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide
 0.15      
50 1049 620 0.591 12.40 26.0 23.378
Cyclophosphamide
 0.6       
10 210 235 1.119 23.50 26.5 133.598
Trend: -1.203        
Probability: 0.885