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Study Information
Study Attribute Value
CEBS Accession Number: 002-02875-0002-0000-6
Chemical Name: Tetrachlorodiphenylethane
CASRN: 72-54-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 624997_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 05/07/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Tetrachlorodiphenylethane 
10         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
16         
 200 4 0.020 1.5 0 0.000 0.0 4 0.020 1.5 0 0.000 0.0 
30         
 200 4 0.020 1.5 0 0.000 0.0 4 0.020 1.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 38 0.190 15.5 15 0.075 6.5 23 0.115 10.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 17 0.340 34.0 2 0.040 4.0 15 0.300 30.0 0 0.000 0.0
Trend: 0.556 0.000 0.556  
Probability: 0.289 0.000 0.289  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/07/1986    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Test Chemical: Tetrachlorodiphenylethane 
10         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
16         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0 
30         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 20 0.100 10.0 4 0.020 2.0 16 0.080 8.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 19 0.380 34.0 7 0.140 12.0 12 0.240 24.0 0 0.000 0.0
Trend: 0.268 0.243 0.160  
Probability: 0.395 0.404 0.437