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Study Information
Study Attribute Value
CEBS Accession Number: 002-02876-0001-0000-6
Chemical Name: Tetrachloroethylene
CASRN: 127-18-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 214014_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/14/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 453 0.433 9.06 25.8 0.000
Test Chemical Tetrachloroethylene 
16.4       
 50 1042 424 0.407 8.48 25.8 -6.042 
54.5       
 50 1042 440 0.422 8.80 25.8 -2.497 
164         
 50 1042 424 0.407 8.48 25.8 -6.042
Positive Control Triethylenemelamine 
 0.015     
 50 1042 2511 2.410 50.22 25.8 456.432
Trend: -0.699        
Probability: 0.758        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/14/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1033 388 0.376 7.76 26.0 0.000
Test Chemical Tetrachloroethylene 
5.45      
 50 1033 394 0.381 7.88 26.0 1.546 
16.4       
 50 1028 388 0.377 7.76 26.0 0.486 
54.5       
 50 1004 399 0.397 7.98 26.0 5.805
Positive Control Cyclophosphamide 
1.5       
 50 1035 1286 1.243 25.72 26.0 230.803
Trend: 0.713        
Probability: 0.238        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 08/10/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 460 0.441 9.20 25.5 0.000
Test Chemical Tetrachloroethylene 
80.36      
 50 1049 461 0.439 9.22 25.5 -0.356 
95.12      
 0 0 0 0.000 0.00 25.5 N/A 
109.9       
 50 1033 425 0.411 8.50 25.5 -6.714 
124.6       
 50 1042 432 0.415 8.64 25.5 -5.997
Positive Control Cyclophosphamide 
1.5       
 50 1042 1439 1.381 28.78 25.5 213.126
Trend: -1.279        
Probability: 0.900