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Study Information
Study Attribute Value
CEBS Accession Number: 002-02876-0017-0000-3
Chemical Name: Tetrachloroethylene
CASRN: 127-18-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 053083_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 01/05/93 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0097
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 3.00 ± 0.93 0.0002
Test Chemical Tetrachloroethylene 
1000         
 8 0.25 ± 0.25 0.1585
  
1500         
 8 0.25 ± 0.25 0.1585
  
2000         
 8 2.50 ± 0.73 0.0007
  
2500         
 7 0.29 ± 0.29 0.1424
Vehicle Control No Stressor 
 0         
 8 0.00 ± 0.00 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 06/02/93 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.8945
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 3.75 ± 1.33 0.0053
  
200         
 8 7.00 ± 1.51 0.0000
Test Chemical Tetrachloroethylene 
1500         
 8 0.25 ± 0.25 0.9108
  
2000         
 8 0.75 ± 0.53 0.6479
  
2500         
 8 0.25 ± 0.25 0.9108
Vehicle Control No Stressor 
 0         
 8 1.00 ± 0.53 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 09/14/93 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.9891
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 6.75 ± 1.56 0.0021
  
200         
 8 9.75 ± 1.79 0.0000
Test Chemical Tetrachloroethylene 
1500         
 8 1.00 ± 0.76 0.9471
  
2000         
 8 1.50 ± 0.63 0.8438
  
2500         
 8 0.50 ± 0.33 0.9900
Vehicle Control No Stressor 
 0         
 8 2.50 ± 0.82 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed