COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02876-0017-0000-3
Chemical Name: Tetrachloroethylene
CASRN: 127-18-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 053083_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 01/05/93 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0097
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 3.00 ± 0.93 0.0002
Test Chemical Tetrachloroethylene 
1000         
 8 0.25 ± 0.25 0.1585
  
1500         
 8 0.25 ± 0.25 0.1585
  
2000         
 8 2.50 ± 0.73 0.0007
  
2500         
 7 0.29 ± 0.29 0.1424
Vehicle Control No Stressor 
 0         
 8 0.00 ± 0.00 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 06/02/93 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.8945
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 3.75 ± 1.33 0.0053
  
200         
 8 7.00 ± 1.51 0.0000
Test Chemical Tetrachloroethylene 
1500         
 8 0.25 ± 0.25 0.9108
  
2000         
 8 0.75 ± 0.53 0.6479
  
2500         
 8 0.25 ± 0.25 0.9108
Vehicle Control No Stressor 
 0         
 8 1.00 ± 0.53 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 09/14/93 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.9891
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 6.75 ± 1.56 0.0021
  
200         
 8 9.75 ± 1.79 0.0000
Test Chemical Tetrachloroethylene 
1500         
 8 1.00 ± 0.76 0.9471
  
2000         
 8 1.50 ± 0.63 0.8438
  
2500         
 8 0.50 ± 0.33 0.9900
Vehicle Control No Stressor 
 0         
 8 2.50 ± 0.82 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed