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Study Information
Study Attribute Value
CEBS Accession Number: 002-02877-0001-0000-7
Chemical Name: Tetrachlorophthalic anhydride
CASRN: 117-08-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 996344_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 02/17/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 462 0.441 9.24 26.0 0.000
Test Chemical Tetrachlorophthalic anhydride 
25         
 50 1049 458 0.437 9.16 26.0 -1.055 
75         
 50 1050 427 0.407 8.54 26.0 -7.840 
250         
 50 1050 455 0.433 9.10 26.0 -1.797 
750         
 50 1048 417 0.398 8.34 26.0 -9.826
Positive Control Mitomycin-C 
 0.005     
 25 523 518 0.990 20.72 26.0 124.457
Trend: -1.398        
Probability: 0.919        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/17/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 473 0.453 9.46 26.0 0.000
Test Chemical Tetrachlorophthalic anhydride 
25         
 50 1049 539 0.514 10.78 26.0 13.519 
75         
 50 1045 520 0.498 10.40 26.0 9.937 
250         
 50 1049 509 0.485 10.18 26.0 7.201 
750         
 50 1047 590 0.564 11.80 26.0 24.497
Positive Control Cyclophosphamide 
1         
 50 1048 763 0.728 15.26 26.0 60.849
Trend: 2.771        
Probability: 0.003        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 06/10/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 404 0.387 8.08 26.0 0.000
Test Chemical Tetrachlorophthalic anhydride 
125         
 50 1042 389 0.373 7.78 26.0 -3.436 
250         
 50 1048 448 0.427 8.96 26.0 10.574 
500         
 50 1043 429 0.411 8.58 26.0 6.392
Positive Control Cyclophosphamide 
1.5       
 50 1049 1355 1.292 27.10 26.0 234.117
Trend: 1.467        
Probability: 0.071