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Study Information
Study Attribute Value
CEBS Accession Number: 002-02877-0002-0000-8
Chemical Name: Tetrachlorophthalic anhydride
CASRN: 117-08-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 996344_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 02/17/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Tetrachlorophthalic anhydride 
75         
 100 6 0.060 6.0 2 0.020 2.0 4 0.040 4.0 0 0.000 0.0 
250         
 100 5 0.050 5.0 0 0.000 0.0 5 0.050 5.0 0 0.000 0.0 
750         
 100 7 0.070 7.0 0 0.000 0.0 7 0.070 7.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 100 27 0.270 23.0 8 0.080 8.0 19 0.190 16.0 0 0.000 0.0
Trend: 0.776 -1.307 1.363  
Probability: 0.219 0.904 0.087  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/10/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Tetrachlorophthalic anhydride 
75         
 100 6 0.060 6.0 0 0.000 0.0 6 0.060 6.0 0 0.000 0.0 
125         
 100 9 0.090 6.0 3 0.030 3.0 6 0.060 4.0 0 0.000 0.0 
250         
 100 9 0.090 6.0 2 0.020 2.0 7 0.070 6.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 25 0.250 22.0 9 0.090 9.0 16 0.160 14.0 0 0.000 0.0
Trend: 1.217 1.034 1.469  
Probability: 0.112 0.151 0.071  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 02/17/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Tetrachlorophthalic anhydride 
25         
 100 5 0.050 4.0 3 0.030 1.0 2 0.020 2.0 0 0.000 0.0 
75         
 100 6 0.060 6.0 1 0.010 1.0 5 0.050 5.0 0 0.000 0.0 
250         
 100 8 0.080 8.0 2 0.020 2.0 6 0.060 6.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 18 0.180 13.0 4 0.040 4.0 14 0.140 10.0 0 0.000 0.0
Trend: 1.375 0.611 1.365  
Probability: 0.085 0.271 0.086