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Study Information
Study Attribute Value
CEBS Accession Number: 002-02878-0001-0000-8
Chemical Name: Tetrachlorvinphos
CASRN: 961-11-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 724074_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/06/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1030 482 0.468 9.64 26.0 0.000
Test Chemical Tetrachlorvinphos 
2         
 50 1035 472 0.456 9.44 26.0 -2.548 
6.7       
 50 1033 460 0.445 9.20 26.0 -4.841 
20         
 50 1023 567 0.554 11.34 31.0 18.440 
66.7       
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1018 643 0.632 12.86 26.0 34.975
Mitomycin-C 
 0.01      
 5 105 153 1.457 30.60 26.0 211.381
Trend: 2.499        
Probability: 0.006        

Trial #: 2    Activation: No Activation    Date: 03/27/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1028 431 0.419 8.62 26.0 0.000
Test Chemical Tetrachlorvinphos 
39.8       
 50 1021 468 0.458 9.36 26.0 9.329 
49.8       
 50 1030 601 0.583 12.02 26.0 39.172 
60         
 50 1026 639 0.623 12.78 26.0 48.549
Positive Control Mitomycin-C 
 0.001     
 50 1018 605 0.594 12.10 26.0 41.750
Mitomycin-C 
 0.01      
 5 101 160 1.584 32.00 26.0 277.846
Trend: 7.345        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/06/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1014 503 0.496 10.06 26.0 0.000
Test Chemical Tetrachlorvinphos 
6.7       
 50 1021 516 0.505 10.32 26.0 1.881 
20         
 50 1032 543 0.526 10.86 26.0 6.069 
66.7       
 50 1027 585 0.570 11.70 26.0 14.830 
200         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1009 607 0.602 12.14 26.0 21.274
Cyclophosphamide 
2         
 5 102 149 1.461 29.80 26.0 194.480
Trend: 2.396        
Probability: 0.008