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Study Information
Study Attribute Value
CEBS Accession Number: 002-02878-0002-0000-9
Chemical Name: Tetrachlorvinphos
CASRN: 961-11-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 724074_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Negative 

Trial #:1   Activation: No Activation    Date: 05/13/1986    Harvest Time: 10 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 9 0.045 3.5 2 0.010 1.0 6 0.030 2.0 1 0.005 0.5
Dimethyl Sulfoxide 
0         
 200 17 0.085 6.0 5 0.025 2.5 10 0.050 2.5 2 0.010 1.0
Test Chemical: Tetrachlorvinphos 
50.3       
 200 9 0.045 3.0 4 0.020 1.5 4 0.020 1.5 1 0.005 0.5 
74.7       
 200 10 0.050 5.0 3 0.015 1.5 1 0.005 0.5 6 0.030 3.0 
100.5       
 200 4 0.020 2.0 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 
150         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 200 64 0.320 24.0 22 0.110 9.5 41 0.205 17.0 1 0.005 0.5
Mitomycin-C 
 0.75      
 25 15 0.600 52.0 4 0.160 16.0 10 0.400 36.0 1 0.040 4.0
Trend: -1.552 -1.122 -2.027  
Probability: 0.940 0.869 0.979  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/22/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Tetrachlorvinphos 
20         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
50         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0 
75         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
100         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 15 0.075 7.0 2 0.010 1.0 13 0.065 6.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 10 0.400 32.0 2 0.080 8.0 8 0.320 28.0 0 0.000 0.0
Trend: 1.040 1.223 0.622  
Probability: 0.149 0.111 0.267  


Trial #:2   Activation: No Activation    Date: 04/17/1986    Harvest Time: 20 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Tetrachlorvinphos 
24.8       
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
49.7       
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0 
74.2       
 200 8 0.040 4.0 3 0.015 1.5 5 0.025 2.5 0 0.000 0.0 
99         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 30 0.150 12.0 18 0.090 8.5 12 0.060 5.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 9 0.360 28.0 7 0.280 24.0 2 0.080 8.0 0 0.000 0.0
Trend: 2.359 2.205 1.384  
Probability: 0.009 0.014 0.083