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Study Information
Study Attribute Value
CEBS Accession Number: 002-02885-0001-0000-6
Chemical Name: Tetraethylthiuram disulfide
CASRN: 97-77-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 038371_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 08/24/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1052 409 0.389 8.18 26.0 0.000
Test Chemical Tetraethylthiuram disulfide 
 0.001     
 50 1048 394 0.376 7.88 26.0 -3.300 
 0.005     
 50 1048 375 0.358 7.50 26.0 -7.963 
 0.016     
 50 1046 478 0.457 9.56 26.0 17.541
Positive Control Mitomycin-C 
 0.005     
 25 526 610 1.160 24.40 26.0 198.289
Trend: 1.971        
Probability: 0.024        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/18/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 473 0.451 9.46 26.0 0.000
Test Chemical Tetraethylthiuram disulfide 
 0.115     
 50 1051 467 0.444 9.34 26.0 -1.456 
 0.36      
 50 1047 456 0.436 9.12 26.0 -3.410 
1.15      
 50 1045 484 0.463 9.68 26.0 2.717
Positive Control Cyclophosphamide 
1         
 50 1046 895 0.856 17.90 26.0 89.760
Trend: 0.304        
Probability: 0.381