COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02885-0002-0000-7
Chemical Name: Tetraethylthiuram disulfide
CASRN: 97-77-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 038371_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 08/24/1983    Harvest Time: 14 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: Tetraethylthiuram disulfide 
 0.005     
 100 12 0.120 12.0 1 0.010 1.0 11 0.110 11.0 0 0.000 0.0 
 0.016     
 100 15 0.150 12.0 1 0.010 1.0 14 0.140 11.0 0 0.000 0.0 
 0.05      
 100 20 0.200 15.0 2 0.020 2.0 18 0.180 13.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 50 29 0.580 30.0 7 0.140 10.0 21 0.420 26.0 1 0.020 1.0
Trend: 2.382 1.347 2.035  
Probability: 0.009 0.089 0.021  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/18/1983    Harvest Time: 14 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Tetraethylthiuram disulfide 
 0.36      
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
1.15      
 100 7 0.070 7.0 0 0.000 0.0 7 0.070 7.0 0 0.000 0.0 
3.6       
 100 18 0.180 17.0 14 0.140 13.0 4 0.040 4.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 50 14 0.280 26.0 4 0.080 8.0 10 0.200 20.0 0 0.000 0.0
Trend: 3.457 4.108 0.781  
Probability: 0.000 0.000 0.218