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Study Information
Study Attribute Value
CEBS Accession Number: 002-02885-0002-0000-7
Chemical Name: Tetraethylthiuram disulfide
CASRN: 97-77-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 038371_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 08/24/1983    Harvest Time: 14 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: Tetraethylthiuram disulfide 
 0.005     
 100 12 0.120 12.0 1 0.010 1.0 11 0.110 11.0 0 0.000 0.0 
 0.016     
 100 15 0.150 12.0 1 0.010 1.0 14 0.140 11.0 0 0.000 0.0 
 0.05      
 100 20 0.200 15.0 2 0.020 2.0 18 0.180 13.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 50 29 0.580 30.0 7 0.140 10.0 21 0.420 26.0 1 0.020 1.0
Trend: 2.382 1.347 2.035  
Probability: 0.009 0.089 0.021  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/18/1983    Harvest Time: 14 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Tetraethylthiuram disulfide 
 0.36      
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
1.15      
 100 7 0.070 7.0 0 0.000 0.0 7 0.070 7.0 0 0.000 0.0 
3.6       
 100 18 0.180 17.0 14 0.140 13.0 4 0.040 4.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 50 14 0.280 26.0 4 0.080 8.0 10 0.200 20.0 0 0.000 0.0
Trend: 3.457 4.108 0.781  
Probability: 0.000 0.000 0.218