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Study Information
Study Attribute Value
CEBS Accession Number: 002-02887-0001-0000-8
Chemical Name: Tetrahydrofuran
CASRN: 109-99-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 378945_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 05/05/1982    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Water
0         
50 1051 489 0.465 9.78 26.0 0.000
Test Chemical Tetrahydrofuran
500         
50 1047 393 0.375 7.86 26.0 -19.325
1600         
50 1048 434 0.414 8.68 26.0 -10.993
5000         
50 1047 421 0.402 8.42 26.0 -13.577
Positive Control Mitomycin-C
 0.005     
50 1050 1174 1.118 23.48 26.0 140.310
Trend: -1.698        
Probability: 0.955        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/29/1982    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Water
0         
100 2093 1023 0.489 10.23 26.0 0.000
Test Chemical Tetrahydrofuran
500         
50 1050 506 0.482 10.12 26.0 -1.405
1600         
50 1047 519 0.496 10.38 26.0 1.418
5000         
50 1049 543 0.518 10.86 26.0 5.905
Positive Control Cyclophosphamide
1         
100 2086 1492 0.715 14.92 26.0 46.335
Trend: 1.039        
Probability: 0.149