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Study Information
Study Attribute Value
CEBS Accession Number: 002-02887-0001-0000-8
Chemical Name: Tetrahydrofuran
CASRN: 109-99-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 378945_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 05/05/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1051 489 0.465 9.78 26.0 0.000
Test Chemical Tetrahydrofuran 
500         
 50 1047 393 0.375 7.86 26.0 -19.325 
1600         
 50 1048 434 0.414 8.68 26.0 -10.993 
5000         
 50 1047 421 0.402 8.42 26.0 -13.577
Positive Control Mitomycin-C 
 0.005     
 50 1050 1174 1.118 23.48 26.0 140.310
Trend: -1.698        
Probability: 0.955        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/29/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 100 2093 1023 0.489 10.23 26.0 0.000
Test Chemical Tetrahydrofuran 
500         
 50 1050 506 0.482 10.12 26.0 -1.405 
1600         
 50 1047 519 0.496 10.38 26.0 1.418 
5000         
 50 1049 543 0.518 10.86 26.0 5.905
Positive Control Cyclophosphamide 
1         
 100 2086 1492 0.715 14.92 26.0 46.335
Trend: 1.039        
Probability: 0.149