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Study Information
Study Attribute Value
CEBS Accession Number: 002-02887-0002-0000-9
Chemical Name: Tetrahydrofuran
CASRN: 109-99-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 378945_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Questionable 
No Activation  2  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 09/16/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: Tetrahydrofuran 
3000         
 100 7 0.070 7.0 2 0.020 2.0 5 0.050 5.0 0 0.000 0.0 
4000         
 100 9 0.090 7.0 0 0.000 0.0 9 0.090 7.0 0 0.000 0.0 
5000         
 100 9 0.090 6.0 4 0.040 2.0 5 0.050 5.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 50 26 0.520 40.0 5 0.100 10.0 21 0.420 32.0 0 0.000 0.0
Trend: 0.581 0.831 0.538  
Probability: 0.281 0.203 0.295  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 09/16/1982    Harvest Time: 14 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Tetrahydrofuran 
1000         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
2000         
 100 6 0.060 6.0 2 0.020 2.0 4 0.040 4.0 0 0.000 0.0 
3000         
 100 12 0.120 12.0 3 0.030 3.0 9 0.090 9.0 0 0.000 0.0 
4000         
 100 8 0.080 7.0 2 0.020 2.0 6 0.060 6.0 0 0.000 0.0 
5000         
 100 12 0.120 8.0 3 0.030 2.0 9 0.090 8.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 21 0.210 18.0 6 0.060 5.0 15 0.150 13.0 0 0.000 0.0
Trend: 2.139 1.479 2.105  
Probability: 0.016 0.070 0.018  


Trial #:2   Activation: No Activation    Date: 04/29/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 100 7 0.070 7.0 2 0.020 2.0 5 0.050 5.0 0 0.000 0.0
Test Chemical: Tetrahydrofuran 
500         
 100 8 0.080 8.0 0 0.000 0.0 8 0.080 8.0 0 0.000 0.0 
1600         
 100 17 0.170 16.0 3 0.030 3.0 14 0.140 14.0 0 0.000 0.0 
5000         
 100 8 0.080 8.0 3 0.030 3.0 5 0.050 5.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 50 23 0.460 30.0 7 0.140 10.0 16 0.320 22.0 0 0.000 0.0
Trend: 0.838 0.961 0.504  
Probability: 0.201 0.168 0.307  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 04/29/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 100 8 0.080 8.0 2 0.020 2.0 6 0.060 6.0 0 0.000 0.0
Test Chemical: Tetrahydrofuran 
500         
 100 11 0.110 7.0 3 0.030 2.0 8 0.080 6.0 0 0.000 0.0 
1600         
 100 11 0.110 10.0 4 0.040 4.0 7 0.070 7.0 0 0.000 0.0 
5000         
 100 13 0.130 13.0 3 0.030 3.0 10 0.100 10.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 28 0.280 23.0 9 0.090 9.0 19 0.190 16.0 0 0.000 0.0
Trend: 1.372 0.686 1.119  
Probability: 0.085 0.246 0.131