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Study Information
Study Attribute Value
CEBS Accession Number: 002-02887-0015-0000-3
Chemical Name: Tetrahydrofuran
CASRN: 109-99-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 720076_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 02/19/87 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.9079
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 6.00 ± 1.60 0.0123
Test Chemical Tetrahydrofuran 
500         
 8 2.75 ± 0.84 0.5000
  
1000         
 8 0.75 ± 0.37 0.9845
  
2000         
 8 1.75 ± 1.22 0.8299
Vehicle Control No Stressor 
 0         
 8 2.75 ± 0.65 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 03/09/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.4326
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 8.00 ± 1.51 0.0000
Test Chemical Tetrahydrofuran 
500         
 8 0.75 ± 0.53 0.5000
  
1000         
 8 1.75 ± 0.59 0.1015
  
2000         
 8 0.75 ± 0.53 0.5000
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.53 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed