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Study Information
Study Attribute Value
CEBS Accession Number: 002-02888-0001-0000-9
Chemical Name: Tetrakis(hydroxymethyl)phosphonium chloride
CASRN: 124-64-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 523400_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 01/23/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1051 395 0.376 7.90 26.5 0.000
Test Chemical Tetrakis(hydroxymethyl)phosphonium chloride 
4.99      
 50 1044 465 0.445 9.30 26.5 18.511 
15         
 50 1040 397 0.382 7.94 26.5 1.569 
49.9       
 50 1051 1060 1.009 21.20 30.5 168.354
Positive Control Mitomycin-C 
 0.0015    
 50 1045 687 0.657 13.74 26.5 74.923
Mitomycin-C 
 0.01      
 20 419 639 1.525 31.95 26.5 305.782
Trend: 18.116        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 02/06/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1045 379 0.363 7.58 26.0 0.000
Test Chemical Tetrakis(hydroxymethyl)phosphonium chloride 
20         
 50 1042 587 0.563 11.74 26.0 55.327 
30         
 50 1040 803 0.772 16.06 26.0 112.892 
39.9       
 50 1047 1221 1.166 24.42 30.0 221.548
Positive Control Mitomycin-C 
 0.0015    
 50 1049 611 0.582 12.22 26.5 60.599
Mitomycin-C 
 0.01      
 10 211 290 1.374 29.00 26.5 278.959
Trend: 22.117        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/23/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1047 341 0.326 6.82 26.0 0.000
Test Chemical Tetrakis(hydroxymethyl)phosphonium chloride 
4.99      
 50 1047 378 0.361 7.56 26.0 10.850 
15         
 50 1044 407 0.390 8.14 26.0 19.698 
49.9       
 50 1040 995 0.957 19.90 26.0 193.753
Positive Control Cyclophosphamide 
 0.5       
 50 1045 394 0.377 7.88 26.0 15.764
Cyclophosphamide 
2.5       
 50 1046 533 0.510 10.66 26.0 56.454
Trend: 19.649        
Probability: 0.000