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Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02888-0002-0000-0 |
Chemical Name: | Tetrakis(hydroxymethyl)phosphonium chloride |
CASRN: | 124-64-1 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 523400_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
Induced Rat Liver S9 | 1_S9 | Questionable |
No Activation | 2 | Positive |
No Activation | 3 | Weakly Positive |
Dose µg/mL |
Total Cells Examined |
Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
||||
Vehicle Control: | Negative (Not Specified) | 0 |
200 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 1 | 0.005 | 1.0 |
Test Chemical: | Tetrakis(hydroxymethyl)phosphonium chloride | 9.99 |
200 | 5 | 0.025 | 2.0 | 0 | 0.000 | 0.0 | 5 | 0.025 | 2.0 | 0 | 0.000 | 0.0 |
30 |
50 | 25 | 0.500 | 32.0 | 12 | 0.240 | 22.0 | 13 | 0.260 | 18.0 | 0 | 0.000 | 0.0 | ||
40 |
100 | 44 | 0.440 | 25.0 | 19 | 0.190 | 15.0 | 15 | 0.150 | 13.0 | 10 | 0.100 | 1.0 | ||
50 |
0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.2 |
50 | 136 | 2.720 | 78.0 | 23 | 0.460 | 32.0 | 43 | 0.860 | 52.0 | 70 | 1.400 | 7.0 |
Mitomycin-C | 1 |
15 | 150 | 10.000 | 100.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 150 | 10.000 | 15.0 | |
Trend: | 8.644 | 7.881 | 5.652 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |
Dose µg/mL |
Total Cells Examined |
Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
||||
Vehicle Control: | Negative (Not Specified) | 0 |
100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Tetrakis(hydroxymethyl)phosphonium chloride | 10 |
100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
30 |
100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
50 |
100 | 6 | 0.060 | 6.0 | 2 | 0.020 | 2.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | ||
150 |
15 | 5 | 0.333 | 27.0 | 2 | 0.133 | 13.0 | 3 | 0.200 | 20.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 50 |
50 | 56 | 1.120 | 44.0 | 22 | 0.440 | 30.0 | 23 | 0.460 | 32.0 | 11 | 0.220 | 2.0 |
Trend: | 3.748 | 3.093 | 2.922 | ||||||||||||
Probability: | 0.000 | 0.001 | 0.002 |
Dose µg/mL |
Total Cells Examined |
Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
||||
Vehicle Control: | Negative (Not Specified) | 0 |
100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Tetrakis(hydroxymethyl)phosphonium chloride | 15 |
100 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
30 |
100 | 7 | 0.070 | 6.0 | 0 | 0.000 | 0.0 | 7 | 0.070 | 6.0 | 0 | 0.000 | 0.0 | ||
45 |
99 | 20 | 0.202 | 19.0 | 3 | 0.030 | 3.0 | 17 | 0.172 | 16.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 5 |
50 | 48 | 0.960 | 56.0 | 15 | 0.300 | 26.0 | 33 | 0.660 | 40.0 | 0 | 0.000 | 0.0 |
Trend: | 5.231 | 1.625 | 4.943 | ||||||||||||
Probability: | 0.000 | 0.052 | 0.000 |
Dose µg/mL |
Total Cells Examined |
Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
||||
Vehicle Control: | Negative (Not Specified) | 0 |
100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Tetrakis(hydroxymethyl)phosphonium chloride | 10 |
100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
30 |
100 | 10 | 0.100 | 10.0 | 1 | 0.010 | 1.0 | 9 | 0.090 | 9.0 | 0 | 0.000 | 0.0 | ||
50 |
90 | 4 | 0.044 | 4.0 | 0 | 0.000 | 0.0 | 4 | 0.044 | 4.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 5 |
50 | 20 | 0.400 | 28.0 | 7 | 0.140 | 12.0 | 13 | 0.260 | 20.0 | 0 | 0.000 | 0.0 |
Trend: | 2.297 | 0.698 | 2.186 | ||||||||||||
Probability: | 0.011 | 0.243 | 0.014 |