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Study Information
Study Attribute Value
CEBS Accession Number: 002-02894-0001-0000-6
Chemical Name: Tetranitromethane
CASRN: 509-14-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 247313_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/17/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1030 497 0.483 9.94 25.5 0.000
Test Chemical Tetranitromethane 
 0.5031    
 50 1016 530 0.522 10.60 25.5 8.109 
1.7       
 50 1028 627 0.610 12.54 25.5 26.402 
5         
 50 1035 813 0.786 16.26 25.5 62.791 
16.8       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1029 620 0.603 12.40 25.5 24.870
Mitomycin-C 
 0.01      
 5 105 245 2.333 49.00 25.5 383.568
Trend: 9.187        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/06/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 513 203 0.396 8.12 26.0 0.000
Test Chemical Tetranitromethane 
2.5       
 25 516 223 0.432 8.92 26.0 9.214 
5         
 25 512 332 0.648 13.28 33.1 63.866 
7.5       
 25 511 396 0.775 15.84 33.1 95.837 
10         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 25 518 256 0.494 10.24 26.0 24.891
Mitomycin-C 
 0.01      
 5 102 200 1.961 40.00 26.0 395.509
Trend: 9.237        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/17/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1024 494 0.482 9.88 25.5 0.000
Test Chemical Tetranitromethane 
1.7       
 50 1032 467 0.453 9.34 25.5 -6.198 
5         
 50 1011 499 0.494 9.98 25.5 2.311 
16.8       
 50 1035 484 0.468 9.68 25.5 -3.066 
50.3       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1018 655 0.643 13.10 25.5 33.373
Cyclophosphamide 
2         
 5 103 195 1.893 39.00 25.5 292.437
Trend: -0.059        
Probability: 0.523