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Study Information
Study Attribute Value
CEBS Accession Number: 002-02900-0002-0000-5
Chemical Name: Theophylline
CASRN: 58-55-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 298713_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Negative 

Trial #:1   Activation: No Activation    Date: 06/05/1984    Harvest Time: 22 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 5 0.050 4.0 0 0.000 0.0 4 0.040 3.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 14 0.140 11.0 4 0.040 4.0 10 0.100 7.0 0 0.000 0.0
Test Chemical: Theophylline 
510         
 100 7 0.070 6.0 2 0.020 2.0 3 0.030 3.0 2 0.020 2.0 
555         
 100 8 0.080 6.0 2 0.020 2.0 4 0.040 2.0 2 0.020 2.0 
600         
 100 9 0.090 8.0 3 0.030 3.0 2 0.020 2.0 4 0.040 4.0
Positive Control: Mitomycin-C 
 0.025     
 100 22 0.220 16.0 12 0.120 10.0 10 0.100 9.0 0 0.000 0.0
Mitomycin-C 
 0.063     
 25 25 1.000 36.0 10 0.400 24.0 5 0.200 20.0 10 0.400 1.0
Trend: -0.761 -0.417 -1.953  
Probability: 0.777 0.662 0.975  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/05/1984    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Theophylline 
510         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
555         
 100 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 
600         
 100 5 0.050 4.0 2 0.020 2.0 3 0.030 3.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 100 22 0.220 17.0 4 0.040 4.0 15 0.150 13.0 3 0.030 3.0
Cyclophosphamide 
37.5       
 50 26 0.520 32.0 13 0.260 20.0 13 0.260 20.0 0 0.000 0.0
Trend: 0.400 -0.007 0.982  
Probability: 0.345 0.503 0.163  


Trial #:2   Activation: No Activation    Date: 07/10/1984    Harvest Time: 22 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 8 0.080 5.0 1 0.010 1.0 6 0.060 3.0 0 0.000 0.0
Test Chemical: Theophylline 
510         
 100 4 0.040 4.0 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 
555         
 100 4 0.040 3.0 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 
600         
 100 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0
Positive Control: Mitomycin-C 
 0.025     
 100 12 0.120 7.0 5 0.050 4.0 7 0.070 5.0 0 0.000 0.0
Mitomycin-C 
 0.063     
 50 24 0.480 36.0 11 0.220 22.0 12 0.240 22.0 1 0.020 1.0
Trend: -1.217 0.007 -1.808  
Probability: 0.888 0.497 0.965