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Study Information
Study Attribute Value
CEBS Accession Number: 002-02900-0019-0000-3
Chemical Name: Theophylline
CASRN: 58-55-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 356530_SCE
Study Result: Positive (Nonstandard Protocol)


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 03/14/84 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.61 ± 0.475
Test Chemical Theophylline 
62.5       
 4 6.18 ± 0.429
  
125         
 4 7.64 ± 0.843
  
250         
 4 8.47 ± 0.444
Positive Control Dimethylbenzanthracene 
2.5       
 4 9.39 ± 0.794


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed