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Study Information
Study Attribute Value
CEBS Accession Number: 002-02900-0020-0000-5
Chemical Name: Theophylline
CASRN: 58-55-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 356530_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 03/22/84 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.1182
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
200         
 8 13.75 ± 3.39 0.0000
Test Chemical Theophylline 
62.5       
 8 2.00 ± 0.58 0.5536
  
125         
 8 2.50 ± 0.73 0.3168
  
250         
 7 3.14 ± 0.86 0.1602
Vehicle Control No Stressor 
 0         
 8 2.00 ± 0.93 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 02/04/91 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.8273
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
25         
 8 14.25 ± 3.39 0.0000
Test Chemical Theophylline 
37.5       
 8 3.50 ± 1.05 0.1451
  
75         
 8 2.00 ± 0.93 0.5968
  
150         
 8 1.75 ± 0.59 0.6932
Vehicle Control No Stressor 
 0         
 8 2.25 ± 1.16 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed