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Study Information
Study Attribute Value
CEBS Accession Number: 002-02912-0001-0000-7
Chemical Name: Titanium dioxide
CASRN: 13463-67-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 766516_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 02/05/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1042 424 0.407 8.48 25.5 0.000
Test Chemical Titanium dioxide 
2.5       
 50 1032 372 0.360 7.44 25.5 -11.414 
8.3       
 50 1032 410 0.397 8.20 25.5 -2.365 
25         
 50 1035 420 0.406 8.40 25.5 -0.273
Positive Control Mitomycin-C 
 0.001     
 50 1034 498 0.482 9.96 25.5 18.362
Mitomycin-C 
 0.01      
 5 103 225 2.184 45.00 25.5 436.843
Trend: 0.382        
Probability: 0.351        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/05/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1038 394 0.380 7.88 25.5 0.000
Test Chemical Titanium dioxide 
2.5       
 50 1041 362 0.348 7.24 25.5 -8.387 
8.3       
 50 1038 381 0.367 7.62 25.5 -3.299 
25         
 50 1042 380 0.365 7.60 25.5 -3.924
Positive Control Cyclophosphamide 
 0.4       
 50 1035 623 0.602 12.46 25.5 58.580
Cyclophosphamide 
2         
 5 102 142 1.392 28.40 25.5 266.766
Trend: -0.298        
Probability: 0.617