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Study Information
Study Attribute Value
CEBS Accession Number: 002-02912-0002-0000-8
Chemical Name: Titanium dioxide
CASRN: 13463-67-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 766516_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Questionable 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 05/08/1985    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 3.0 1 0.010 1.0 3 0.030 2.0 0 0.000 0.0
Medium 
0         
 100 5 0.050 3.0 0 0.000 0.0 2 0.020 2.0 2 0.020 2.0
Test Chemical: Titanium dioxide 
15         
 100 14 0.140 7.0 2 0.020 2.0 12 0.120 6.0 0 0.000 0.0 
20         
 100 8 0.080 6.0 3 0.030 3.0 5 0.050 4.0 0 0.000 0.0 
25         
 100 10 0.100 7.0 7 0.070 6.0 3 0.030 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.5       
 100 35 0.350 23.0 7 0.070 7.0 24 0.240 17.0 4 0.040 4.0
Mitomycin-C 
1         
 25 16 0.640 44.0 7 0.280 24.0 9 0.360 28.0 0 0.000 0.0
Trend: 1.048 2.571 -0.225  
Probability: 0.147 0.005 0.589  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/12/1985    Harvest Time: 12.5 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 9 0.090 6.0 1 0.010 1.0 8 0.080 6.0 0 0.000 0.0
Medium 
0         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Titanium dioxide 
15         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
20         
 100 17 0.170 13.0 8 0.080 8.0 9 0.090 7.0 0 0.000 0.0 
25         
 100 6 0.060 6.0 3 0.030 3.0 3 0.030 3.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 100 13 0.130 11.0 3 0.030 3.0 10 0.100 8.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 23 0.920 48.0 6 0.240 24.0 6 0.240 24.0 11 0.440 8.0
Trend: 1.458 1.766 0.536  
Probability: 0.072 0.039 0.296  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 03/27/1985    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Medium 
0         
 100 6 0.060 6.0 1 0.010 1.0 5 0.050 5.0 0 0.000 0.0
Test Chemical: Titanium dioxide 
15         
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 
20         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
25         
 100 5 0.050 5.0 2 0.020 2.0 3 0.030 3.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 100 29 0.290 20.0 10 0.100 6.0 19 0.190 16.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 37 1.480 60.0 5 0.200 16.0 22 0.880 48.0 10 0.400 4.0
Trend: -0.609 0.136 -0.808  
Probability: 0.729 0.446 0.791