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Study Information
Study Attribute Value
CEBS Accession Number: 002-02912-0011-0000-8
Chemical Name: Titanium dioxide
CASRN: 13463-67-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 860815_SCE
Study Result: Negative (Nonstandard Protocol)


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 07/26/89 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.39 ± 0.507
Test Chemical Titanium dioxide 
625         
 4 4.53 ± 0.350
  
1250         
 4 4.59 ± 0.178
  
2500         
 4 3.87 ± 0.261
Positive Control Dimethylbenzanthracene 
2.5       
 4 6.99 ± 0.877


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed