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Study Information
Study Attribute Value
CEBS Accession Number: 002-02912-0012-0000-9
Chemical Name: Titanium dioxide
CASRN: 13463-67-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 860815_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/07/89 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.3533
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
25         
 4 12.50 ± 1.89 0.0000
Test Chemical Titanium dioxide 
625         
 8 1.75 ± 0.70 0.4427
  
1250         
 8 0.75 ± 0.53 0.8465
  
2500         
 8 2.00 ± 0.76 0.3562
Vehicle Control No Stressor 
 0         
 5 1.60 ± 0.75 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/16/89 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.3691
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 13.00 ± 0.76 0.0000
Test Chemical Titanium dioxide 
625         
 8 1.50 ± 0.50 0.6101
  
1250         
 8 1.25 ± 0.53 0.7196
  
2500         
 8 2.00 ± 0.53 0.3972
Vehicle Control No Stressor 
 0         
 8 1.75 ± 0.70 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed