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Study Information
Study Attribute Value
CEBS Accession Number: 002-02913-0001-0000-8
Chemical Name: Titanocene dichloride
CASRN: 1271-19-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 241636_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 04/08/1989    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1050 433 0.412 8.66 26.0 2.849
Dimethyl Sulfoxide 
0         
 50 1045 419 0.401 8.38 26.0 0.000
Test Chemical Titanocene dichloride 
10         
 50 1046 479 0.458 9.58 26.0 14.211 
33         
 50 1043 450 0.431 9.00 26.0 7.605 
100         
 50 1047 479 0.457 9.58 26.0 14.101 
333         
 0 0 0 0.000 0.00 0.0 N/A 
1000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1051 696 0.662 13.92 26.0 65.161
Mitomycin-C 
 0.005     
 10 209 280 1.340 28.00 26.0 234.129
Trend: 1.555        
Probability: 0.060        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/04/1989    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1054 481 0.456 9.62 26.0 0.000
Negative (Not Specified) 
0         
 50 1047 470 0.449 9.40 26.0 -1.634
Test Chemical Titanocene dichloride 
33         
 50 1048 468 0.447 9.36 26.0 -2.146 
100         
 50 1054 490 0.465 9.80 26.0 1.871 
333         
 50 1046 432 0.413 8.64 26.0 -9.500 
1000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.125     
 50 1045 705 0.675 14.10 26.0 47.832
Cyclophosphamide 
 0.5       
 10 209 219 1.048 21.90 26.0 129.611
Trend: -1.234        
Probability: 0.891