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Study Information
Study Attribute Value
CEBS Accession Number: 002-02914-0001-0000-9
Chemical Name: Tolazamide
CASRN: 1156-19-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 225955_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 10/08/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 472 0.450 9.44 27.5 0.000
Test Chemical Tolazamide 
16         
 50 1050 512 0.488 10.24 27.5 8.371 
50         
 50 1052 515 0.490 10.30 27.5 8.799 
160         
 50 1050 516 0.491 10.32 27.5 9.218 
500         
 50 1048 558 0.532 11.16 27.5 18.333 
1600         
 0 0 0 0.000 0.00 32.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1048 620 0.592 12.40 27.5 31.481
Mitomycin-C 
 0.005     
 10 210 260 1.238 26.00 27.5 175.161
Trend: 2.467        
Probability: 0.007        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/08/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 478 0.456 9.56 26.0 0.000
Test Chemical Tolazamide 
160         
 50 1048 473 0.451 9.46 26.0 -1.046 
500         
 50 1050 454 0.432 9.08 26.0 -5.202 
1600         
 50 1048 511 0.488 10.22 26.0 6.904 
2500         
 50 1047 473 0.452 9.46 26.0 -0.952
Positive Control Cyclophosphamide 
 0.15      
 50 1049 739 0.704 14.78 26.0 54.455
Cyclophosphamide 
 0.6       
 10 209 314 1.502 31.40 26.0 229.395
Trend: 0.546        
Probability: 0.293