Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02914-0002-0000-0 |
Chemical Name: | Tolazamide |
CASRN: | 1156-19-0 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 225955_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Tolazamide | 1000 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
1600 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
2500 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.0625 | 200 | 22 | 0.110 | 9.0 | 6 | 0.030 | 3.0 | 16 | 0.080 | 7.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.125 | 50 | 11 | 0.220 | 18.0 | 7 | 0.140 | 12.0 | 4 | 0.080 | 8.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.598 | -1.345 | 1.341 | ||||||||||||
Probability: | 0.275 | 0.911 | 0.090 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Test Chemical: | Tolazamide | 1000 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
1600 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
2500 | 200 | 6 | 0.030 | 2.0 | 1 | 0.005 | 0.5 | 5 | 0.025 | 1.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 5 | 200 | 44 | 0.220 | 18.5 | 11 | 0.055 | 5.5 | 33 | 0.165 | 15.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 7.5 | 50 | 15 | 0.300 | 26.0 | 3 | 0.060 | 6.0 | 12 | 0.240 | 20.0 | 0 | 0.000 | 0.0 | |
Trend: | 1.823 | 1.333 | 1.398 | ||||||||||||
Probability: | 0.034 | 0.091 | 0.081 |