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Study Information
Study Attribute Value
CEBS Accession Number: 002-02915-0002-0000-1
Chemical Name: Tolbutamide
CASRN: 64-77-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 481185_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 10/10/1985    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 7 0.035 3.0 2 0.010 1.0 5 0.025 2.5 0 0.000 0.0
Test Chemical: Tolbutamide 
148         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0 
494         
 200 10 0.050 5.0 2 0.010 1.0 8 0.040 4.0 0 0.000 0.0 
1480         
 200 9 0.045 4.5 1 0.005 0.5 8 0.040 4.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 200 74 0.370 26.0 15 0.075 7.0 49 0.245 20.0 10 0.050 1.0
Mitomycin-C 
5         
 50 38 0.760 48.0 9 0.180 16.0 29 0.580 42.0 0 0.000 0.0
Trend: 1.285 -0.186 1.191  
Probability: 0.099 0.574 0.117  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/10/1985    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 5 0.025 2.5 2 0.010 1.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: Tolbutamide 
148         
 200 9 0.045 3.5 2 0.010 1.0 7 0.035 3.0 0 0.000 0.0 
494         
 200 12 0.060 6.0 3 0.015 1.5 9 0.045 4.5 0 0.000 0.0 
1480         
 200 9 0.045 4.0 2 0.010 1.0 7 0.035 3.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 54 1.080 54.0 6 0.120 12.0 28 0.560 42.0 20 0.400 2.0
Trend: 1.154 0.160 1.380  
Probability: 0.124 0.437 0.084