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Study Information
Study Attribute Value
CEBS Accession Number: 002-02923-0001-0000-9
Chemical Name: p-Anisidine
CASRN: 104-94-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 366940_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 12/08/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 417 0.398 8.34 26.0 0.000
Test Chemical p-Anisidine 
1.6       
 50 1044 481 0.461 9.62 26.0 15.679 
5         
 50 1049 477 0.455 9.54 26.0 14.170 
16         
 50 1037 628 0.606 12.56 26.0 52.052
Positive Control Mitomycin-C 
 0.005     
 25 523 732 1.400 29.28 26.0 251.415
Trend: 6.423        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 01/19/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 430 0.411 8.60 26.0 0.000
Test Chemical p-Anisidine 
14         
 50 1045 613 0.587 12.26 26.0 42.695 
16         
 50 1047 649 0.620 12.98 26.0 50.786 
18         
 50 1041 835 0.802 16.70 26.0 95.119 
20         
 50 1038 724 0.697 14.48 26.0 69.670
Positive Control Mitomycin-C 
 0.005     
 25 522 599 1.148 23.96 26.0 179.138
Trend: 10.337        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/08/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 460 0.439 9.20 26.0 0.000
Test Chemical p-Anisidine 
50         
 50 1049 459 0.438 9.18 26.0 -0.217 
160         
 50 1045 597 0.571 11.94 26.0 30.279 
500         
 50 1046 678 0.648 13.56 26.0 47.814
Positive Control Cyclophosphamide 
1         
 50 1048 1061 1.012 21.22 26.0 130.872
Trend: 7.628        
Probability: 0.000