Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02923-0001-0000-9 |
Chemical Name: | p-Anisidine |
CASRN: | 104-94-9 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 366940_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Weakly Positive |
No Activation | 2 | Positive |
Induced Rat Liver S9 | 1_S9 | Positive |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1047 | 417 | 0.398 | 8.34 | 26.0 | 0.000 |
Test Chemical | p-Anisidine | 1.6 | 50 | 1044 | 481 | 0.461 | 9.62 | 26.0 | 15.679 |
5 | 50 | 1049 | 477 | 0.455 | 9.54 | 26.0 | 14.170 | ||
16 | 50 | 1037 | 628 | 0.606 | 12.56 | 26.0 | 52.052 | ||
Positive Control | Mitomycin-C | 0.005 | 25 | 523 | 732 | 1.400 | 29.28 | 26.0 | 251.415 |
Trend: | 6.423 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1046 | 430 | 0.411 | 8.60 | 26.0 | 0.000 |
Test Chemical | p-Anisidine | 14 | 50 | 1045 | 613 | 0.587 | 12.26 | 26.0 | 42.695 |
16 | 50 | 1047 | 649 | 0.620 | 12.98 | 26.0 | 50.786 | ||
18 | 50 | 1041 | 835 | 0.802 | 16.70 | 26.0 | 95.119 | ||
20 | 50 | 1038 | 724 | 0.697 | 14.48 | 26.0 | 69.670 | ||
Positive Control | Mitomycin-C | 0.005 | 25 | 522 | 599 | 1.148 | 23.96 | 26.0 | 179.138 |
Trend: | 10.337 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1049 | 460 | 0.439 | 9.20 | 26.0 | 0.000 |
Test Chemical | p-Anisidine | 50 | 50 | 1049 | 459 | 0.438 | 9.18 | 26.0 | -0.217 |
160 | 50 | 1045 | 597 | 0.571 | 11.94 | 26.0 | 30.279 | ||
500 | 50 | 1046 | 678 | 0.648 | 13.56 | 26.0 | 47.814 | ||
Positive Control | Cyclophosphamide | 1 | 50 | 1048 | 1061 | 1.012 | 21.22 | 26.0 | 130.872 |
Trend: | 7.628 | ||||||||
Probability: | 0.000 |