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Study Information
Study Attribute Value
CEBS Accession Number: 002-02930-0001-0000-7
Chemical Name: Triallyl isocyanurate
CASRN: 1025-15-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 652546_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Test Failure 
No Activation  3  Negative 
No Activation  4  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 05/13/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 469 0.448 9.38 26.5 0.000
Test Chemical Triallyl isocyanurate 
29.7       
 50 1050 544 0.518 10.88 26.5 15.660 
99         
 50 1047 582 0.556 11.64 26.5 24.094 
297         
 50 1052 540 0.513 10.80 26.5 14.591 
990         
 0 0 0 0.000 0.00 26.5 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1046 625 0.598 12.50 26.5 33.390
Mitomycin-C 
 0.01      
 10 210 319 1.519 31.90 26.5 239.114
Trend: 2.410        
Probability: 0.008        

Trial #: 2    Activation: No Activation    Date: 06/18/1986    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 476 0.456 9.52 26.5 0.000
Test Chemical Triallyl isocyanurate 
205         
 50 1048 492 0.469 9.84 26.5 3.065 
410         
 50 1047 506 0.483 10.12 26.5 6.099 
615         
 50 1044 538 0.515 10.76 26.5 13.133 
820         
 0 0 0 0.000 0.00 30.5 N/A
Positive Control Mitomycin-C 
 0.0015    
 100 2074 1101 0.531 11.01 26.5 16.543
Mitomycin-C 
 0.01      
 10 210 182 0.867 18.20 26.5 90.266
Trend: 1.976        
Probability: 0.024        

Trial #: 3    Activation: No Activation    Date: 09/03/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1030 472 0.458 9.44 26.5 0.000
Test Chemical Triallyl isocyanurate 
403         
 50 1038 474 0.457 9.48 26.5 -0.350 
505         
 50 1040 525 0.505 10.50 26.5 10.159 
605         
 50 1038 482 0.464 9.64 26.5 1.332 
705         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1028 879 0.855 17.58 26.5 86.591
Mitomycin-C 
 0.01      
 10 212 763 3.599 76.30 26.5 685.387
Trend: 0.763        
Probability: 0.223        

Trial #: 4    Activation: No Activation    Date: 03/03/1988    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1039 388 0.373 7.76 26.5 0.000
Test Chemical Triallyl isocyanurate 
50.5       
 50 1037 310 0.299 6.20 26.5 -19.949 
101         
 50 1028 356 0.346 7.12 26.5 -7.266 
201         
 50 1026 335 0.327 6.70 26.5 -12.566
Positive Control Mitomycin-C 
 0.0015    
 50 1040 696 0.669 13.92 26.5 79.209
Mitomycin-C 
 0.01      
 10 207 498 2.406 49.80 26.5 544.233
Trend: -1.161        
Probability: 0.877        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/20/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 432 0.415 8.64 26.0 0.000
Test Chemical Triallyl isocyanurate 
29.1       
 50 1049 461 0.439 9.22 26.0 6.001 
97         
 50 1045 509 0.487 10.18 26.0 17.486 
291         
 50 1047 486 0.464 9.72 26.0 11.963 
970         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.5       
 50 1047 638 0.609 12.76 26.0 46.980
Cyclophosphamide 
2.5       
 10 210 295 1.405 29.50 26.0 238.834
Trend: 2.139        
Probability: 0.016