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Study Information
Study Attribute Value
CEBS Accession Number: 002-02934-0001-0000-1
Chemical Name: Tribromomethane
CASRN: 75-25-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 845432_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 06/10/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 459 0.439 9.18 26.0 0.000
Test Chemical Tribromomethane 
16         
 50 1048 496 0.473 9.92 26.0 7.752 
50         
 50 1049 500 0.477 10.00 26.0 8.517 
160         
 50 1051 514 0.489 10.28 26.0 11.343
Positive Control Triethylenemelamine 
 0.015     
 50 1044 1781 1.706 35.62 26.0 288.389
Trend: 1.614        
Probability: 0.053        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/10/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 431 0.411 8.62 26.0 0.000
Test Chemical Tribromomethane 
50         
 50 1049 461 0.439 9.22 26.0 6.859 
160         
 50 1049 498 0.475 9.96 26.0 15.435 
500         
 50 1049 493 0.470 9.86 26.0 14.276
Positive Control Cyclophosphamide 
1         
 50 1049 1165 1.111 23.30 26.0 170.044
Trend: 2.288        
Probability: 0.011