COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02934-0003-0000-3
Chemical Name: Tribromomethane
CASRN: 75-25-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 973869_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 08/23/1981    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1039 427 0.411 8.54 25.5 0.000
Test Chemical Tribromomethane 
29         
 50 1034 470 0.455 9.40 25.5 10.603 
96.8       
 50 1035 499 0.482 9.98 25.5 17.313 
290         
 50 1030 528 0.513 10.56 25.5 24.734
Positive Control Triethylenemelamine 
 0.015     
 50 1021 3071 3.008 61.42 25.5 631.883
Trend: 3.508        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/23/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1004 441 0.439 8.82 25.5 0.000
Test Chemical Tribromomethane 
96.8       
 50 1025 497 0.485 9.94 25.5 10.389 
290         
 50 1020 454 0.445 9.08 30.5 1.333 
968         
 50 1027 531 0.517 10.62 30.5 17.712
Positive Control Cyclophosphamide 
1.5       
 50 1035 1629 1.574 32.58 25.5 258.324
Trend: 2.045        
Probability: 0.020