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Study Information
Study Attribute Value
CEBS Accession Number: 002-02941-0001-0000-9
Chemical Name: Trichlorfon
CASRN: 52-68-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 183626_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 04/03/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1040 362 0.348 7.24 26.5 -11.438
Medium 
0         
 50 1033 406 0.393 8.12 26.5 0.000
Test Chemical Trichlorfon 
1.6       
 50 1044 524 0.502 10.48 26.5 27.704 
5         
 50 1045 550 0.526 11.00 26.5 33.912 
16         
 50 1049 639 0.609 12.78 26.5 54.989 
50         
 50 1040 1013 0.974 20.26 26.5 147.828 
160         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1047 1457 1.392 29.14 26.5 254.068
Mitomycin-C 
 0.01      
 10 210 708 3.371 70.80 26.5 757.804
Trend: 16.671        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 05/09/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1044 419 0.401 8.38 26.0 0.000
Negative (Not Specified) 
0         
 50 1046 430 0.411 8.60 26.0 2.429
Test Chemical Trichlorfon 
10         
 50 1046 489 0.467 9.78 26.0 16.483 
25         
 50 1040 593 0.570 11.86 26.0 42.072 
50         
 50 1045 982 0.940 19.64 26.0 134.143 
100         
 50 1049 1386 1.321 27.72 31.0 229.211 
150         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1046 1313 1.255 26.26 26.0 212.766
Mitomycin-C 
 0.01      
 10 209 644 3.081 64.40 26.0 667.761
Trend: 27.203        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/03/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1041 416 0.400 8.32 26.0 -0.336
Medium 
0         
 50 1040 417 0.401 8.34 26.0 0.000
Test Chemical Trichlorfon 
50         
 50 1044 495 0.474 9.90 26.0 18.250 
160         
 50 1047 517 0.494 10.34 26.0 23.152 
500         
 50 1046 710 0.679 14.20 26.0 69.287 
1600         
 50 1047 1385 1.323 27.70 26.0 229.914 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1040 595 0.572 11.90 26.0 42.686
Cyclophosphamide 
2         
 10 209 290 1.388 29.00 26.0 246.058
Trend: 25.513        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 05/08/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1046 449 0.429 8.98 26.0 25.728
Medium 
0         
 50 1031 352 0.341 7.04 26.0 0.000
Test Chemical Trichlorfon 
1000         
 50 1037 1241 1.197 24.82 26.0 250.517 
3000         
 50 1037 1925 1.856 38.50 26.0 443.711 
4000         
 50 1042 1712 1.643 34.24 31.0 381.229 
5000         
 50 1038 1634 1.574 32.68 31.0 361.074
Positive Control Cyclophosphamide 
 0.3       
 50 1050 600 0.571 12.00 26.0 67.370
Cyclophosphamide 
2         
 10 210 326 1.552 32.60 26.0 354.689
Trend: 29.406        
Probability: 0.000