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Study Information
Study Attribute Value
CEBS Accession Number: 002-02941-0002-0000-0
Chemical Name: Trichlorfon
CASRN: 52-68-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 183626_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive* 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 04/17/1984    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Medium 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Trichlorfon 
16         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
50         
 100 2 0.020 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
160         
 100 8 0.080 6.0 3 0.030 3.0 5 0.050 4.0 0 0.000 0.0 
500         
 100 50 0.500 36.0 1 0.010 1.0 49 0.490 36.0 0 0.000 0.0 
1600         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 100 67 0.670 46.0 34 0.340 27.0 32 0.320 26.0 1 0.010 1.0
Trend: 7.830 1.277 7.948  
Probability: 0.000 0.101 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/06/1984    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Medium 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Trichlorfon 
1600         
 100 13 0.130 11.0 6 0.060 6.0 7 0.070 6.0 0 0.000 0.0 
3000         
 100 68 0.680 51.0 36 0.360 28.0 32 0.320 27.0 0 0.000 0.0 
4000         
 100 229 2.290 86.0 121 1.210 66.0 98 0.980 65.0 10 0.100 1.0 
5000         
 100 275 2.750 82.0 124 1.240 56.0 120 1.200 67.0 31 0.310 4.0
Positive Control: Cyclophosphamide 
15         
 100 43 0.430 28.0 28 0.280 20.0 15 0.150 12.0 0 0.000 0.0
Cyclophosphamide 
50         
 50 53 1.060 56.0 41 0.820 50.0 12 0.240 20.0 0 0.000 0.0
Trend: 15.379 11.886 12.696  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 05/31/1984    Harvest Time: 12.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Medium 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Trichlorfon 
200         
 100 7 0.070 6.0 1 0.010 1.0 6 0.060 5.0 0 0.000 0.0 
300         
 100 14 0.140 14.0 0 0.000 0.0 14 0.140 14.0 0 0.000 0.0 
400         
 100 55 0.550 42.0 9 0.090 8.0 46 0.460 37.0 0 0.000 0.0 
500         
 100 68 0.680 50.0 6 0.060 6.0 62 0.620 46.0 0 0.000 0.0 
750         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 100 58 0.580 37.0 38 0.380 26.0 20 0.200 17.0 0 0.000 0.0
Mitomycin-C 
1         
 50 41 0.820 52.0 27 0.540 46.0 13 0.260 22.0 1 0.020 1.0
Trend: 10.151 3.466 9.581  
Probability: 0.000 0.000 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 04/17/1984    Harvest Time: 12.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Medium 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Trichlorfon 
160         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
500         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
1600         
 100 11 0.110 10.0 3 0.030 3.0 8 0.080 7.0 0 0.000 0.0 
5000         
 100 233 2.330 87.0 98 0.980 59.0 112 1.120 72.0 23 0.230 5.0
Positive Control: Cyclophosphamide 
15         
 100 29 0.290 21.0 11 0.110 9.0 18 0.180 16.0 0 0.000 0.0
Cyclophosphamide 
50         
 50 40 0.800 46.0 30 0.600 40.0 10 0.200 16.0 0 0.000 0.0
Trend: 13.891 11.524 12.228  
Probability: 0.000 0.000 0.000