Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02941-0011-0000-0
Chemical Name:	Trichlorfon
CASRN:	52-68-6
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	383555
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	90	117	95	35	36
			96	107	96	33
			81	88	90	37
			71	89	80	38
Test Chemical	Trichlorfon	31.25	91	106	89	32	35
			104	94	118	38	35
		62.5	75	99	78	35	34
			99	115	102	34	34
		125	94	104	113	40	46
			82	80	127	52	46
		250	83	43	356	143	144*
			75	47	329	146	144*
		500	42	7	498	397	367*
			54	7	549	337	367*
Positive Control	Methyl Methane Sulfonate	15	40	18	424	350	386*
Positive Control			31	14	397	422	386*

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	61	81	82	45	38
			82	100	91	37
			96	111	69	24
			72	108	100	46
Test Chemical	Trichlorfon	200	94	65	370	131	170*
			72	41	448	209	170*
		300	59	20	533	301	299*
			52	15	458	296	299*
		500	22	3	204	307	294*
			29	5	246	281	294*
		600	11	1	448	1378	1062*
			19	3	418	746	1062*
Positive Control	Methyl Methane Sulfonate	15	31	28	162	172	150*
Positive Control			44	38	168	128	150*

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination